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Taking it with other medicines - Sequential combined HRT

There are some medicines that may affect how your HRT works because they can sometimes cause irregular bleeding.

Tell your GP or pharmacist if you're taking any other medicines, including:

  • epilepsy medicines
  • medicines for tuberculosis
  • medicines for HIV and Hepatitis C
  • some antibiotics and antifungal medicines
  • some medicines that prevent transplant rejection, such as ciclosporin

Sequential combined HRT and herbal remedies

St John's wort may stop HRT tablets from working as well.

It's not possible to say that other herbal remedies and supplements are safe to take with HRT.

They're not tested in the same way as pharmacy or prescription medicines. They're generally not tested for the effect they can have on other medicines.

Any herbal product may affect other medicines you're taking, so it's important to check with your doctor or pharmacist before starting to take them.

Alternatives to HRT

Medicine safety

Tell your GP or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 1 June 2025
Next review due: 1 June 2028