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Taking amitriptyline with other medicines

Some medicines affect amitriptyline and can increase the chance of you having side effects.

Make sure that your GP or pharmacist knows that you're taking amitriptyline before you start or stop any other medicine.

Tell your GP or pharmacist before taking amitriptyline if you:

  • are on any other medicine
  • have taken any other medicines in the last 14 days

If you are going to have a general or local anaesthetic as part of surgery or dental treatment, tell your doctor or dentist that you are taking amitriptyline.

Herbal remedies and supplements

Do not take St John's wort while you're taking amitriptyline. St John's wort is a herbal remedy often taken for depression. It will increase your risk of side effects.

Page last reviewed: 9 June 2024
Next review due: 9 June 2027