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Taking sertraline with other medicines

Tell your GP or pharmacist if you are taking any other medicines, including herbal remedies, vitamins or supplements.

Some medicines can react with sertraline. This can increase your chance of side effects.

Talk to your GP or a pharmacist before taking sertraline if you take:

  • medicines that affect your heartbeat - sertraline can speed up or change your heartbeat
  • other medicines for depression - some antidepressants can interfere with sertraline to cause very high blood pressure

Recreational drugs and sertraline

Sertraline does not seem to be affected by cannabis, although you might feel a little more sleepy.

Sertraline may reduce the effects of ecstasy and so might make people try higher doses and get more side effects.

St John's wort and sertraline

Do not take St John's wort, the herbal remedy for depression, while you are being treated with sertraline. This will increase your risk of side effects.

Page last reviewed: 3 July 2024
Next review due: 3 July 2027