Statins

Statins are a group of medicines used to lower levels of cholesterol in your blood.

They are taken to treat and prevent cardiovascular diseases (CVD) including heart attacks and strokes.

A GP may prescribe statins if:

  • you have high cholesterol
  • you have been diagnosed with a form of CVD
  • you're likely to develop CVD and lifestyle measures such as diet and exercise have not reduced this risk

Statins are prescription-only and come as tablets.

Types of statins

Statins available in Ireland include:

  • atorvastatin (also called Lipitor or Atorvas)
  • rosuvastatin (also called Crestor or Rosuva)
  • pravastatin (also called Pravitin or Pravamel)
  • simvastatin (also called Zocor, Sivatin, Simator or Simtan)
  • fluvastatin (also called Lescol or Fluvastenol)

Uses of statins

Statins work by reducing your liver's production of low-density lipoprotein (LDL), often called 'bad cholesterol'.

They also work by reducing other types of fat in the blood called triglycerides.

They are used to treat and prevent different forms of CVD. CVD is a general term that describes a disease of the heart or blood vessels. It's a leading cause of death in Ireland.

The main types of CVD are:

  • coronary heart disease – when blood supply to the heart is restricted
  • angina – chest pain caused by reduced blood flow to the heart muscles
  • heart attacks – when supply of blood to the heart is suddenly blocked
  • stroke – when supply of blood to the brain is blocked

Get emergency help

You might have to get emergency help if you have serious side effects or an allergic reaction to statins.

Serious side effects

Serious side effects (anaphylaxis) with statins are rare.

Urgent advice: Call a GP urgently and stop taking statins if you get:

  • muscle pain, weakness or cramps, and dark pee - these are dangerous signs, particularly if you also feel unwell or have a high temperature
  • yellow skin or eyes, pale poo or dark pee
  • a severe skin rash with peeling and swelling of the skin, and pink-red blotches, especially on the palms of the hands or soles of the feet
  • severe stomach pain
  • a cough, feeling short of breath, and weight loss
  • unusual bleeding or bruising

Serious allergic reaction

In rare cases it's possible to have a serious allergic reaction to statins.

Immediate action required: Call 112 or 999 or go to an emergency department (ED) if:

  • you get a skin rash
  • you have trouble breathing
  • your mouth, face, lips, tongue or throat start swelling

Check if you can take statins

Statins are not suitable for everyone.

Check with your GP that it's safe to take statins if you:

  • have ever had an allergic reaction to statins or other medicines
  • have liver or kidney problems
  • have severe lung disease or difficulty breathing
  • take medicine for bacterial or viral infections
  • take medicines call fibrates
  • are of Asian origin, such as Japanese, Chinese, Filipino, Vietnamese, Korean or Indian - your GP needs to choose the right start dose of Crestor to suit you
  • over the age of 70 years
  • drink large amounts of alcohol
  • have an underactive thyroid
  • have had muscular side effects when taking a statin in the past
  • have had repeated or unexplained muscle aches or pains, or family history of muscle problems - including fibromyalgia
  • are trying to get pregnant, pregnant, or breastfeeding

Atorvastatin is also not suitable if you've had a stroke, or have phenylketonuria.

How and when to take statins 

Always take statins exactly as your GP or pharmacist has told you. Check with your GP or pharmacist if you are not sure.

Usually, statins should be taken once a day.

Simvastatin, pravastatin and fluvastatin should be taken at night. This is because most of the cholesterol your body produces is during the night time.

Atorvastatin or rosuvastatin can be taken at any time, as long as you stick to the same time every day.

Statins do not usually upset the stomach. You can take them with or without food.

Swallow statin tablets whole with a glass of water.

If you forget to take a dose

Take your missed dose as soon as you remember, unless it's nearly time for the next dose. In this case, skip the missed dose and take your next dose as normal.

Do not take a double dose to make up for a forgotten dose.

If you often forget doses, it may help to set a reminder alarm.

Side effects of statins

Talk to your GP or pharmacist if side effects bother you or do not go away.

Common side effects include:

  • headaches
  • aches and pains
  • feeling or being sick
  • feeling weak or dizzy
  • memory loss
  • nosebleeds
  • sore throat
  • cold-like symptoms such as a runny nose
  • constipation or wind
  • stomach pain, diarrhoea or indigestion

See the patient information leaflet that comes with your medicine for a full list of side effects.

You can report any suspected side effects to the Health Products Regulatory Authority (HPRA).

Taking statins with other medicines 

Some medicines may interfere with statins.

Tell your GP or pharmacist if you are taking, have recently taken or might take any other medicines or supplements.

Tell your GP if you're taking:

  • antibiotics and antifungals
  • HIV medicines
  • medications to treat cancer, such as regorafenib or darolutamide
  • indigestion remedies
  • the contraceptive pill
  • hepatitis C medicines
  • warfarin, clopidogrel or any medicine used for thinning the blood
  • ciclosporin or other medicines that alter your immune system
  • verapamil or diltiazem (medicines used to treat blood pressure or heart problems)
  • amiodarone
  • fibrates such as gemfibrozil or fenofibrate
  • or any other medicine used to lower cholesterol such as ezetimibe
  • colchicine

Statins can also interact with grapefruit juice so you should avoid it, particularly if you are taking simvastatin.

Tell your GP if you take any herbal remedies, vitamins or supplements.

Finding your patient information leaflet online

Your patient information leaflet (PIL) is the leaflet that comes in the package of your medicine. 

Information:

To find your PIL online, visit the Health Products Regulatory Authority (HPRA) website

  1. In the ‘Find a medicine’ search box, enter the brand name of your medicine. A list of matching medicines appears.
  2. To the right of your medicine, select ‘PIL’. A PDF of the PIL opens in a new window. 

You can also:

  1. Select the brand name of your medicine.
  2. Scroll down to the Documents section.
  3. From the Package Leaflet line, select PDF version. A PDF of the PIL opens in a new window. 

If your PIL is not on the HPRA website, the European Medicines Agency (EMA) website opens in a new window when you select ‘PIL’.

You can find your PIL on the EMA website.

Finding your PIL on the EMA website

If your PIL is not on the HPRA website, you will be sent to the European Medicines Agency (EMA) website.

To find your PIL on the EMA website:

  1. In the Medicines search box, enter the brand name of your medicine and the word ‘epar’. For example: ‘Zoely epar’. A list of matching medicines appears.
  2. Select the ‘Human medicine European public assessment report (EPAR)’ for your medicine
  3. From the table of contents, select Product information.
  4. Select the EPAR – Product Information link for your medicine. A PDF opens in a new window. The PIL information is in Annex III of the PDF under ‘labelling and package leaflet’

This content was fact checked by a pharmacist, a GP, the National Medication Safety Programme (Safermeds) and the Health Products Regulatory Authority (HPRA).

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This project has received funding from the Government of Ireland’s Sláintecare Integration Fund 2019 under Grant Agreement Number 123.

Page last reviewed: 24 September 2021
Next review due: 24 September 2024

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