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Mpox vaccine - Mpox

You can get the mpox vaccine if you are:

  • in an at-risk group
  • identified as a close contact of someone who has mpox - health professionals will let you know if you should get a mpox vaccine

Who can get the mpox vaccine

You can get the mpox vaccine if you are both:

  • a man or transgender person who has sex with men, and
  • sexually active and likely to remain sexually active for the next 3 months

One of the following must also apply to you:

  • You have had anal sex without a condom with 2 or more partners in the past 6 months.
  • You are likely to have anal sex without a condom in the next 3 months.
  • You have been diagnosed with a sexually transmitted infection (STI) in the past 12 months, for example gonorrhoea, syphilis or chlamydia.
  • You have had treatment for exposure to HIV in the past 12 months.
  • You have used drugs for sex (also known as chemsex) in the past 6 months.

Get the mpox vaccine

Contact these clinics if you are eligible for an mpox vaccine.

Mater Hospital, Dublin

01 803 2965

70 Eccles Street,
Basement level,
Dublin 7

St. Vincent's Hospital, Dublin


Carew House,
St Vincent's Hospital,
Merrion Rd,
Dublin 4

University Hospital Galway STI clinic

Phone 091 542 294 and ask for the mpox clinic.

Infectious Diseases Clinic,
University Hospital Galway,
Newcastle Road,

About the mpox vaccine

The smallpox vaccine can be used to protect against mpox. This is because mpox is caused by a similar virus to smallpox. When the smallpox vaccine is used for mpox, we call it the mpox vaccine.

How the mpox vaccine is given

Most people will get the vaccine through an injection between layers of skin in your forearm. This is a smaller dose but gives you the same protection as an injection under your skin.

Doses of mpox vaccine

If you are a close contact of someone with mpox, you will get 1 dose of the mpox vaccine. Some close contacts will get 2 doses.

If you book a vaccine you will get 2 doses of the mpox vaccine, at least 28 days apart.

If you had a smallpox vaccine before, you only need 1 dose of the vaccine. But if you have a weak immune system, you will need 2 doses. Vaccines may be less effective for you than other people.

Protection from mpox after vaccine

It takes 14 days after your course of the vaccine for it to work.

There is a chance you might still get mpox, even if you have had the vaccine. But it may reduce any symptoms of mpox.

Who should not get the mpox vaccine

If you have had mpox, you do not need to get the mpox vaccine.

Do not get the mpox vaccine if you have had an allergic reaction to any of the vaccine ingredients, including:

  • chicken protein
  • benzonase
  • gentamicin
  • ciprofloxacin
  • Trometamol

Mpox vaccine side effects

The most common side effects of the vaccine are:

  • headache
  • nausea
  • muscle pain (myalgia)
  • tiredness
  • reactions where you got the vaccine, including pain, redness, swelling, hardening and itching

These may affect more than 1 in 10 people.

Reporting side effects

You can report a side effect on the Health Products Regulatory Authority (HPRA) website.

Report a side effect - hpra.ie

You can report it yourself, or your doctor or family member can do that for you.

Mpox vaccine and COVID-19 vaccines

If you are due a COVID-19 vaccine dose, you can get it 4 weeks after your mpox vaccine.

If you have recently had a COVID-19 vaccine dose, you can get the mpox vaccine any time after this. You do not need to wait 4 weeks.

Page last reviewed: 4 September 2023
Next review due: 20 December 2025